Histology and Pathology

Every cell have a cytoskeleton, a system of fibers that maintains cell structure, shape and allows the movements. Cytoskeleton is made of microtubules, intermediate filaments as keratins and microfilaments. Keratins are abundant in epithelial cells. The M cells were first identified by J.F Schmedtje using Electron microscopy in rabbit appendix tissue. The discovery of the M cells we owe it to Owen & Jones,1974. Studying the Peyer’s Patches (PPs) of human small intestine they found the presence of microfolds on the apical surface of the M cells. The function of gatekeepers was discovered. It has been said that Intestinal epithelial cells in the Follicle associated epithelium (FAE) originate from stem cells in crypts located between a villus and a Peyer's Patch (PP) dome. Each crypt harbours a demilune in front of the pathologist eye made of stem cells that generate distinct cell types from two distinct recognized axes of ...